diff --git a/src/crypto/randomx/jit_compiler_a64.cpp b/src/crypto/randomx/jit_compiler_a64.cpp
index bae695cf1..c4be5ad92 100644
--- a/src/crypto/randomx/jit_compiler_a64.cpp
+++ b/src/crypto/randomx/jit_compiler_a64.cpp
@@ -726,7 +726,16 @@ void JitCompilerA64::h_ISUB_R(Instruction& instr, uint32_t& codePos)
 	}
 	else
 	{
-		emitAddImmediate(dst, dst, -instr.getImm32(), code, k);
+		const uint32_t imm = instr.getImm32();
+
+		if (imm == 0x80000000ul) {
+			constexpr uint32_t tmp_reg = 20;
+			emit32(ARMV8A::MOVZ | tmp_reg | (1u << 21) | (0x8000u << 5), code, k);
+			emit32(ARMV8A::ADD | dst | (dst << 5) | (tmp_reg << 16), code, k);
+		}
+		else {
+			emitAddImmediate(dst, dst, -instr.getImm32(), code, k);
+		}
 	}
 
 	reg_changed_offset[instr.dst] = k;
diff --git a/src/crypto/randomx/jit_compiler_rv64.cpp b/src/crypto/randomx/jit_compiler_rv64.cpp
index 230b22d1b..596deda7b 100644
--- a/src/crypto/randomx/jit_compiler_rv64.cpp
+++ b/src/crypto/randomx/jit_compiler_rv64.cpp
@@ -814,9 +814,16 @@ namespace randomx {
 			state.emit(rvi(rv64::SUB, regR(isn.dst), regR(isn.dst), regR(isn.src)));
 		}
 		else {
-			int32_t imm = unsigned32ToSigned2sCompl(-isn.getImm32()); //convert to add
-			//x{dst} = x{dst} + {-imm}
-			emitImm32(state, imm, regR(isn.dst), regR(isn.dst), Tmp1Reg);
+			const uint32_t uimm = isn.getImm32();
+			if (uimm == 0x80000000ul) {
+				state.emit(rv64::LUI | (0x80000 << 12) | rvrd(Tmp1Reg));
+				state.emit(rvi(rv64::SUB, regR(isn.dst), regR(isn.dst), Tmp1Reg));
+			}
+			else {
+				int32_t imm = unsigned32ToSigned2sCompl(-uimm); //convert to add
+				//x{dst} = x{dst} + {-imm}
+				emitImm32(state, imm, regR(isn.dst), regR(isn.dst), Tmp1Reg);
+			}
 		}
 	}
 
diff --git a/src/crypto/randomx/jit_compiler_rv64_vector.cpp b/src/crypto/randomx/jit_compiler_rv64_vector.cpp
index e177a0f2d..bc9f68f19 100644
--- a/src/crypto/randomx/jit_compiler_rv64_vector.cpp
+++ b/src/crypto/randomx/jit_compiler_rv64_vector.cpp
@@ -444,6 +444,12 @@ void* generateProgramVectorRV64(uint8_t* buf, Program& prog, ProgramConfiguratio
 				// sub x20 + dst, x20 + dst, x20 + src
 				emit32(0x414A0A33 + (dst << 7) + (dst << 15) + (src << 20));
 			}
+			else if (imm == 0x80000000U) {
+				// lui x5, 0x80000000U
+				emit32(0x800002B7);
+				// sub x20 + dst, x20 + dst, x5
+				emit32(0x405A0A33 + (dst << 7) + (dst << 15));
+			}
 			else {
 				imm_to_x5(-imm, p);
 				// c.add x20 + dst, x5
diff --git a/src/crypto/randomx/randomx.h b/src/crypto/randomx/randomx.h
index 51998e298..4b23b37d2 100644
--- a/src/crypto/randomx/randomx.h
+++ b/src/crypto/randomx/randomx.h
@@ -163,7 +163,7 @@ extern RandomX_ConfigurationGraft RandomX_GraftConfig;
 extern RandomX_ConfigurationSafex RandomX_SafexConfig;
 extern RandomX_ConfigurationYada RandomX_YadaConfig;
 
-extern RandomX_ConfigurationBase RandomX_CurrentConfig;
+alignas(64) extern RandomX_ConfigurationBase RandomX_CurrentConfig;
 
 template<typename T>
 void randomx_apply_config(const T& config)